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Article

AdpA, key regulator for morphological differentiation regulates bacterial chromosome replication.

Open biology - 1 Jul 2012

Wolański Marcin, Jakimowicz Dagmara, Zakrzewska-Czerwińska Jolanta

Abstract excerpt

AdpA, one of the most pleiotropic transcription regulators in bacteria, controls expression of several dozen genes during Streptomyces differentiation. Here, we report a novel function for the AdpA protein: inhibitor of chromosome replication at the initiation stage. AdpA specifically recognizes the 5' region of the Streptomyces coelicolor replication origin (oriC). Our in vitro results show that binding of AdpA...

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Identifiers

PMID: 22870392
DOI: 10.1098/rsob.120097
PMCID: PMC3411110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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