Article
Intracellular autoactivation of TMPRSS11A, an airway epithelial transmembrane serine protease.
The Journal of biological chemistry - 4 Sept 2020
Zhang Ce, Zhang Yikai, Zhang Shengnan, Wang Zhiting, Sun Shijin, Liu Meng, Chen Yue, Dong Ningzheng, Wu Qingyu
Abstract excerpt
Type II transmembrane serine proteases (TTSPs) are a group of enzymes participating in diverse biological processes. Some members of the TTSP family are implicated in viral infection. TMPRSS11A is a TTSP expressed on the surface of airway epithelial cells, which has been shown to cleave and activate spike proteins of the severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome...
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