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Article

Aquaporin 2 promotes cell migration and epithelial morphogenesis.

Journal of the American Society of Nephrology : JASN - 1 Sept 2012

Chen Ying, Rice William, Gu Zhizhan, Li Jian, Huang Jianmin, Brenner Michael B, Van Hoek Alfred, Xiong Jianping, Gundersen Gregg G, Norman Jim C, Hsu Victor W, Fenton Robert A, Brown Dennis, Lu Hua A Jenny

Abstract excerpt

The aquaporin 2 (AQP2) water channel, expressed in kidney collecting ducts, contributes critically to water homeostasis in mammals. Animals lacking or having significantly reduced levels of AQP2, however, have not only urinary concentrating abnormalities but also renal tubular defects that lead to neonatal mortality from renal failure. Here, we show that AQP2 is not only a water channel but also an...

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Source

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Identifiers

PMID: 22859853
DOI: 10.1681/ASN.2012010079
PMCID: PMC3431417

Genes

AQP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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