Article
SLC35A2 Deficiency Promotes an Epithelial-to-Mesenchymal Transition-like Phenotype in Madin-Darby Canine Kidney Cells.
Cells - 23 Jul 2022
Kot Magdalena, Mazurkiewicz Ewa, Wiktor Maciej, Wiertelak Wojciech, Mazur Antonina Joanna, Rahalevich Andrei, Olczak Mariusz, Maszczak-Seneczko Dorota
Abstract excerpt
In mammalian cells, SLC35A2 delivers UDP-galactose for galactosylation reactions that take place predominantly in the Golgi lumen. Mutations in the corresponding gene cause a subtype of a congenital disorder of glycosylation (SLC35A2-CDG). Although more and more patients are diagnosed with SLC35A2-CDG, the link between defective galactosylation and disease symptoms is not fully understood. According to a number...
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