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Article

Inhibition of phosphoinositide-3 kinase pathway down regulates ABCG2 function and sensitizes malignant pleural mesothelioma to chemotherapy.

Lung cancer (Amsterdam, Netherlands) - 1 Oct 2012

Fischer Bruno, Frei Claudia, Moura Ubiratan, Stahel Rolf, Felley-Bosco Emanuela

Abstract excerpt

Malignant pleural mesothelioma (MPM) is a relatively chemoresistant malignancy. Diverse biological targets are under investigation to develop new therapeutic options. One of these targets, namely the phosphoinositide-3-kinase (PI3K) pathway, has been shown to be a regulator of the side population (SP) phenotype in different cancers. The SP phenotype is due to drug efflux abilities providing drug-resistant...

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Source

Identifiers

PMID: 22857894
DOI: 10.1016/j.lungcan.2012.07.005

Genes

ABCG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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