Article
Effects of the glucolipid synthase inhibitor, P4, on functional and phenotypic parameters of murine myeloma cells.
British journal of cancer - 1 Nov 1999
Manning L S, Radin N S
Abstract excerpt
This study describes the effects of the glucolipid synthase inhibitor P4, (DL-threo-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol ), on various functional and phenotypic parameters of 5T33 murine myeloma cells. Cell recovery was reduced by >85% following incubation of the cells for 3 days in the presence of 4 microM P4 (the IC50 concentration). Both cytostatic and cytotoxic inhibition was observed with...
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