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Article

Analysis of ABCG2 expression and side population identifies intrinsic drug efflux in the HCC cell line MHCC-97L and its modulation by Akt signaling

26 Sept 2008

Abstract excerpt

Active drug efflux by the adenosine triphosphate-binding cassette (ABC) transporter ABCG2 is one of the common mechanisms causing multiple drug resistance in various human cancers. In the intrinsic drug resistance of hepatocellular carcinoma (HCC), the role of ABCG2 is closely associated with 'side population (SP)', a minor subset of cancer stem-like cells with unique capacity to extrude lipophilic dye Hoechst...

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PMID: 18820285
DOI: 10.1093/carcin/bgn223

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Related research

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Analysis of ABCG2 expression and side population identifies intrinsic drug efflux in the HCC cell line MHCC-97L and its modulation by Akt signalingPMID 18820285Read ↗

Identification of side population cells in human hepatocellular carcinoma cell lines with stepwise metastatic potentials.Semantic proximity Read ↗

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Tumor initiating potential of side population cells in human gastric cancer.Semantic proximity Read ↗

Side Population Is Enriched in Tumorigenic, Stem-Like Cancer Cells, whereas ABCG2+ and ABCG2− Cancer Cells Are Similarly TumorigenicSemantic proximity Read ↗

Side Population Cells as Prototype of Chemoresistant, Tumor-Initiating CellsSemantic proximity Read ↗

The Human Melanoma Side Population Displays Molecular and Functional Characteristics of Enriched Chemoresistance and TumorigenesisSemantic proximity Read ↗

Dynamic vs Static ABCG2 Inhibitors to Sensitize Drug Resistant Cancer CellsSemantic proximity Read ↗

Characterization of Side Population in Thyroid Cancer Cell Lines: Cancer Stem-Like Cells Are Enriched Partly But Not ExclusivelySemantic proximity Read ↗

Side population in hepatocellular carcinoma HCCLM3 cells is enriched with stem-like cancer cellsSemantic proximity Read ↗

Increased multi-drug resistance and reduced apoptosis in osteosarcoma side population cells are crucial factors for tumor recurrenceSemantic proximity Read ↗

Side population cells of pancreatic cancer show characteristics of cancer stem cells responsible for resistance and metastasis.Semantic proximity Read ↗

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