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Article

Quantification of host proteomic responses to genotype 4 hepatitis E virus replication facilitated by pregnancy serum.

Virology journal - 1 Jun 2023

Qian Zhongyao, Cong Chao, Li Yi, Bi Yanhong, He Qiuxia, Li Tengyuan, Xia Yueping, Xu Liangheng, Mickael Houfack K, Yu Wenhai, Liu Jiankun, Wei Daqiao, Huang Fen

Abstract excerpt

BACKGROUND: Hepatitis E virus (HEV) infection is a common cause of acute hepatitis worldwide and causes approximately 30% case fatality rate among pregnant women. Pregnancy serum (PS), which contains a high concentration of estradiol, facilitates HEV replication in vitro through the suppression of the PI3K-AKT-mTOR and cAMPK-PKA-CREB signaling pathways. However, the proteomics of the complex host responses to HEV...

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Identifiers

PMID: 37264422
DOI: 10.1186/s12985-023-02080-5
PMCID: PMC10233519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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