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Modification of Host Lipid Raft Proteome upon Hepatitis C Virus Replication

30 Aug 2006

Abstract excerpt

Hepatitis C virus (HCV) replication complex resides in detergent-insoluble subcellular domains or lipid rafts. We used two proteomics approaches to characterize the protein content of lipid rafts isolated from Huh7 cells and its modification upon HCV replication. Using two-dimensional electrophoresis and mass spectrometry, we identified approximately 100 protein spots in the isolated lipid rafts; among them, 39...

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PMID: 16943187
DOI: 10.1074/mcp.m600121-mcp200

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