Article
Proteomic analysis of HepaRG cells: a novel cell line that supports hepatitis B virus infection.
Journal of proteome research - 1 Jan 2009
Narayan Ramamurthy, Gangadharan Bevin, Hantz Olivier, Antrobus Robin, García Angela, Dwek Raymond A, Zitzmann Nicole
Abstract excerpt
The first proteomic characterization of the HepaRG cell line, the only cell line that is susceptible to hepatitis B virus (HBV) infection and supports a complete virus life cycle, is reported. Differential analysis of naive and HBV-infected HepaRG cells by two-dimensional gel electrophoresis revealed 19 differentially regulated features, 7 increasing and 12 decreasing with HBV infection. The proteins identified...
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