Article
Combining family and twin data in association studies to estimate the noninherited maternal antigens effect.
Genetic epidemiology - 1 Dec 2012
Balliu Brunilda, Tsonaka Roula, van der Woude Diane, Boehringer Stefan, Houwing-Duistermaat Jeanine J
Abstract excerpt
It is hypothesized that certain alleles can have a protective effect not only when inherited by the offspring but also as noninherited maternal antigens (NIMA). To estimate the NIMA effect, large samples of families are needed. When large samples are not available, we propose a combined approach to estimate the NIMA effect from ascertained nuclear families and twin pairs. We develop a likelihood-based approach...
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