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Article

Participation of Gab1 and Gab2 in IL-22-mediated keratinocyte proliferation, migration, and differentiation.

Molecular and cellular biochemistry - 1 Oct 2012

Zhu Xiaofang, Li Zhongliang, Pan Wenyan, Qin Lu, Zhu Guoqiang, Ke Yuehai, Wu Jie, Bo Ping, Meng Songshu

Abstract excerpt

Interleukin-22 (IL-22) is one of the key mediators of keratinocyte alterations in psoriasis. IL-22 inhibits keratinocyte differentiation and induces the migration of human keratinocytes. Grb2-associated binder 1 (Gab1) has been shown to mediate epidermal growth factor-induced epidermal growth and differentiation via interaction with the Src homology-2-containing protein-tyrosine phosphatase (Shp2). In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22851227
DOI: 10.1007/s11010-012-1389-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Participation of Gab1 and Gab2 in IL-22-mediated keratinocyte proliferation, migration, and differentiation.PMID 22851227Read ↗

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