Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein.

The Journal of biological chemistry - 6 Jan 2006

Brummer Tilman, Schramek Daniel, Hayes Vanessa M, Bennett Haley L, Caldon C Elizabeth, Musgrove Elizabeth A, Daly Roger J

Abstract excerpt

The docking protein Gab2 is a proto-oncogene product that is overexpressed in primary breast cancers. To determine the functional consequences of Gab2 overexpression, we utilized the immortalized human mammary epithelial cell line MCF-10A. In monolayer culture, expression of Gab2 at levels comparable with those detected in human breast cancer cells accelerated epidermal growth factor (EGF)-induced cell cycle...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Breast

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Transformed

Share to Epidermal Growth Factor

Share to Epithelial Cells

Share to Extracellular Signal-Regulated MAP Kinases

Share to Phosphoproteins

Share to Proto-Oncogene Mas

Source

Identifiers

PMID: 16253990
DOI: 10.1074/jbc.M509567200

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein.PMID 16253990Read ↗

A role for the scaffolding adapter GAB2 in breast cancer.Semantic proximity Read ↗

Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activation.Semantic proximity Read ↗

Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor.Semantic proximity Read ↗

Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2.Semantic proximity Read ↗

The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase.Semantic proximity Read ↗

The GAB2 signaling scaffold promotes anchorage independence and drives a transcriptional response associated with metastatic progression of breast cancerSemantic proximity Read ↗

Gab1 signaling is regulated by EGF receptor sorting in early endosomes.Semantic proximity Read ↗

Membrane targeting of Grb2-associated binder-1 (Gab1) scaffolding protein through Src myristoylation sequence substitutes for Gab1 pleckstrin homology domain and switches an epidermal growth factor response to an invasive morphogenic program.Semantic proximity Read ↗

Distinct requirements for Gab1 in Met and EGF receptor signaling <i>in vivo</i>Semantic proximity Read ↗

Participation of Gab1 and Gab2 in IL-22-mediated keratinocyte proliferation, migration, and differentiation.Semantic proximity Read ↗

Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model.Semantic proximity Read ↗

G-CSF stimulates Jak2-dependent Gab2 phosphorylation leading to Erk1/2 activation and cell proliferation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.