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Article

A point mutation in the LIM domain of Lhx3 reduces activation of the glycoprotein hormone alpha-subunit promoter.

The Journal of biological chemistry - 1 Jun 2001

Howard P W, Maurer R A

Abstract excerpt

Lhx3, a member of the LIM homeodomain family of transcription factors, is required for development of the pituitary in mice. A recent report has described a point mutation in the human LHX3 gene that is associated with a combined pituitary hormone disorder. The mutation is predicted to lead to th...

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Source

Identifiers

PMID: 11279219
DOI: 10.1074/jbc.M101782200

Genes

LHX3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11279219-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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A point mutation in the LIM domain of Lhx3 reduces activation of the glycoprotein hormone alpha-subunit promoter.PMID 11279219Read ↗

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LHX3 and LHX4 transcription factors in pituitary development and disease.Semantic proximity Read ↗

Identifying the Deleterious Effect of Rare LHX4 Allelic Variants, a Challenging Issue.Semantic proximity Read ↗

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