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Article

Molecular analysis of LHX3 and PROP-1 in pituitary hormone deficiency patients with posterior pituitary ectopia.

The Journal of clinical endocrinology and metabolism - 1 Aug 2000

Sloop K W, Walvoord E C, Showalter A D, Pescovitz O H, Rhodes S J

Abstract excerpt

The cause of posterior pituitary ectopia associated with anterior pituitary hormone deficiencies is unknown. We describe children with combined pituitary hormone deficiency (CPHD) or isolated GH deficiency. In all cases, magnetic resonance imaging examination revealed abnormal pituitary gland development featuring ectopic posterior lobe location and frequently hypoplastic anterior lobes. Embryonic development of...

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Source

Identifiers

PMID: 10946868
DOI: 10.1210/jcem.85.8.6706

Genes

LHX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular analysis of LHX3 and PROP-1 in pituitary hormone deficiency patients with posterior pituitary ectopia.PMID 10946868Read ↗

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Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency.Semantic proximity Read ↗

Molecular analysis of PROP1, PIT1, HESX1, LHX3, and LHX4 shows high frequency of PROP1 mutations in patients with familial forms of combined pituitary hormone deficiency.Semantic proximity Read ↗

Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development.Semantic proximity Read ↗

LHX3 transcription factor mutations associated with combined pituitary hormone deficiency impair the activation of pituitary target genes.Semantic proximity Read ↗

A novel mutation in the LIM homeobox 3 gene is responsible for combined pituitary hormone deficiency, hearing impairment, and vertebral malformations.Semantic proximity Read ↗

PROP1, HESX1, POU1F1, LHX3 and LHX4 mutation and deletion screening and GH1 P89L and IVS3+1/+2 mutation screening in a Dutch nationwide cohort of patients with combined pituitary hormone deficiency.Semantic proximity Read ↗

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