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Article

LHX3 transcription factor mutations associated with combined pituitary hormone deficiency impair the activation of pituitary target genes.

Gene - 7 Mar 2001

Sloop K W, Parker G E, Hanna K R, Wright H A, Rhodes S J

Abstract excerpt

The Lhx3 LIM homeodomain transcription factor is critical for pituitary gland formation and specification of the anterior pituitary hormone-secreting cell types. Two mutations in LHX3, a missense mutation changing a tyrosine to a cysteine and an intragenic deletion that results in a truncated pro...

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Source

Identifiers

PMID: 11255008
DOI: 10.1016/s0378-1119(01)00369-9

Genes

LHX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11255008-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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LHX3 transcription factor mutations associated with combined pituitary hormone deficiency impair the activation of pituitary target genes.PMID 11255008Read ↗

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Clinical case seminar: a novel LHX3 mutation presenting as combined pituitary hormonal deficiency.Semantic proximity Read ↗

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