Article
Oncogenic potential of the B-cell antigen receptor and its relevance to heavy chain diseases and other B-cell neoplasias: a new model.
Research in immunology - 1 Jan 2000
Corcos D
Abstract excerpt
Some growth factor receptor genes can be activated to become oncogenic as a result of various mutations. The receptors that are encoded by these genes may deliver constitutive signals independent of ligand binding. The model which is presented here assumes that alterations in the B-cell antigen receptor could have similar effects. Evidence that membrane immunoglobulin alterations contribute to oncogenesis in vivo...
Topics
- Gene Rearrangement, B-Lymphocyte
- Heavy Chain Disease
- Humans
- Models, Biological
- Mutation
- Neoplasms
- Oncogenes
- Receptors, Antigen, B-Cell