Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.

doi:10.1371/journal.pgen.1002854

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.

PLoS genetics - 1 Jan 2012

Sandor Cynthia, Li Wanbo, Coppieters Wouter, Druet Tom, Charlier Carole, Georges Michel

Abstract excerpt

We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide recombination rate, genome-wide hotspot usage, and locus-specific recombination rate. We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide...

Topics

Animals
Cattle
Cell Cycle Proteins
Chromosome Mapping
Crossing Over, Genetic
Genetic Linkage
Genome
Histone-Lysine N-Methyltransferase
Homologous Recombination
Humans
Ligases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Miosis

Pedigree

Polymorphism, Single Nucleotide

Quantitative Trait Loci

Sequence Homology, Amino Acid

Sperm Count

Source

Open in PubMed Open full text

Identifiers

PMID: 22844258
DOI: 10.1371/journal.pgen.1002854
PMCID: PMC3406008

Genes

PRDM9
REC8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.PMID 22844258Read ↗

Construction of PRDM9 allele-specific recombination maps in cattle using large-scale pedigree analysis and genome-wide single sperm genomics.Semantic proximity Read ↗

Characterization of recombination features and the genetic basis in multiple cattle breeds.Semantic proximity Read ↗

Coding and noncoding variants in HFM1, MLH3, MSH4, MSH5, RNF212, and RNF212B affect recombination rate in cattle.Semantic proximity Read ↗

Genome-Wide Association Study of Meiotic Recombination Phenotypes.Semantic proximity Read ↗

Sex differences in PRDM9-independent fine-scale recombination patternsSemantic proximity Read ↗

Male recombination map of the autosomal genome in German Holstein.Semantic proximity Read ↗

Genetic analysis of variation in human meiotic recombination.Semantic proximity Read ↗

Variation in human recombination rates and its genetic determinants.Semantic proximity Read ↗

Genome-wide recombination map construction from single sperm sequencing in cattle.Semantic proximity Read ↗

Complete human recombination maps.Semantic proximity Read ↗

Fine-scale recombination rate differences between sexes, populations and individuals.Semantic proximity Read ↗

A fine-scale map of recombination rates and hotspots across the human genome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.