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Article

Predicting the impact of deleterious single point mutations in SMAD gene family using structural bioinformatics approach.

Interdisciplinary sciences, computational life sciences - 1 Jun 2012

George Priya Doss C, Nagasundaram N, Tanwar Himani

Abstract excerpt

Functional alteration in SMAD proteins leads to dis-regulation of its mechanism results in possibilities of high risk diseases like fibrosis, cancer, juvenile polyposis etc. Studying single nucleotide polymorphism (SNP) in SMAD genes helps understand the malfunction of these proteins. In this study, we focused on deleterious effects of nsSNPs in both structural and functional level using publically available...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22843233
DOI: 10.1007/s12539-012-0122-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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