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A luciferase reporter gene assay and aryl hydrocarbon receptor 1 genotype predict the LD50 of polychlorinated biphenyls in avian species.

Toxicology and applied pharmacology - 15 Sept 2012

Manning Gillian E, Farmahin Reza, Crump Doug, Jones Stephanie P, Klein Jeff, Konstantinov Alex, Potter Dave, Kennedy Sean W

Abstract excerpt

Birds differ in sensitivity to the embryotoxic effects of polychlorinated biphenyls (PCBs), which complicates environmental risk assessments for these chemicals. Recent research has shown that the identities of amino acid residues 324 and 380 in the avian aryl hydrocarbon receptor 1 (AHR1) ligand...

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PMID: 22841771
DOI: 10.1016/j.taap.2012.07.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22841771-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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