Article
Phenotypic anchoring of gene expression after developmental exposure to aryl hydrocarbon receptor ligands in zebrafish.
Aquatic toxicology (Amsterdam, Netherlands) - 1 Sept 2010
Bugiak Brandie J, Weber Lynn P
Abstract excerpt
The genes mediating developmental aryl hydrocarbon (AhR)-induced cardiovascular deformities remain unclear, with many cytochrome P450 monooxygenase (CYP)-1 isoforms known to be AhR-responsive and now a cyclo-oxygenase (COX) isoform suspected to contribute developmental toxicity. More importantly, no previous study has examined the role of these genes in producing deformities using low enough concentrations of AhR...
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