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Article

The structure and catalytic cycle of a sodium-pumping pyrophosphatase.

Science (New York, N.Y.) - 27 Jul 2012

Kellosalo Juho, Kajander Tommi, Kogan Konstantin, Pokharel Kisun, Goldman Adrian

Abstract excerpt

Membrane-integral pyrophosphatases (M-PPases) are crucial for the survival of plants, bacteria, and protozoan parasites. They couple pyrophosphate hydrolysis or synthesis to Na(+) or H(+) pumping. The 2.6-angstrom structure of Thermotoga maritima M-PPase in the resting state reveals a previously...

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Identifiers

PMID: 22837527
DOI: 10.1126/science.1222505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22837527-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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