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Article

Active site remodeling during the catalytic cycle in metal-dependent fructose-1,6-bisphosphate aldolases.

The Journal of biological chemistry - 18 May 2018

Jacques Benoit, Coinçon Mathieu, Sygusch Jurgen

Abstract excerpt

Crystal structures of two bacterial metal (Zn2+)-dependent d-fructose-1,6-bisphosphate (FBP) aldolases in complex with substrate, analogues, and triose-P reaction products were determined to 1.5-2.0 Å resolution. The ligand complexes cryotrapped in native or mutant Helicobacter pylori aldolase crystals enabled a novel mechanistic description of FBP C3-C4 bond cleavage. The reaction mechanism uses active site...

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Identifiers

PMID: 29593097
DOI: 10.1074/jbc.RA117.001098
PMCID: PMC5961046

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