Article
Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.
Proceedings of the National Academy of Sciences of the United States of America - 28 Aug 2012
Ko Dennis C, Gamazon Eric R, Shukla Kajal P, Pfuetzner Richard A, Whittington Dale, Holden Tarah D, Brittnacher Mitchell J, Fong Christine, Radey Matthew, Ogohara Cassandra, Stark Amy L, Akey Joshua M, Dolan M Eileen, Wurfel Mark M, Miller Samuel I
Abstract excerpt
Genome-wide association studies can identify common differences that contribute to human phenotypic diversity and disease. When genome-wide association studies are combined with approaches that test how variants alter physiology, biological insights can emerge. Here, we used such an approach to reveal regulation of cell death by the methionine salvage pathway. A common SNP associated with reduced expression of a...
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