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Article

Fibrillization of human tau is accelerated by exposure to lead via interaction with His-330 and His-362.

PloS one - 1 Jan 2011

Zhu Hai-Li, Meng Sheng-Rong, Fan Jun-Bao, Chen Jie, Liang Yi

Abstract excerpt

BACKGROUND: Neurofibrillary tangles, mainly consisted of bundles of filaments formed by the microtubule-associated protein Tau, are a hallmark of Alzheimer disease. Lead is a potent neurotoxin for human being especially for the developing children, and Pb(2+) at high concentrations is found in the brains of patients with Alzheimer disease. However, it has not been reported so far whether Pb(2+) plays a role in...

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PMID: 21966400
DOI: 10.1371/journal.pone.0025020
PMCID: PMC3180286

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