Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acquisition of CD4-dependence by CD4-independent SIV passaged in human peripheral blood mononuclear cells.

Retrovirology - 25 Jul 2012

Iyengar Sujatha, Schwartz David H

Abstract excerpt

BACKGROUND: Chemokine receptors (CKRs), the primordial receptors for primate lentiviruses, are sufficient to mediate virus-cell fusion. Several different fusogenic CKRs and related receptors provide a broad potential host cell range, presumably advantageous for viral spread within a given infecte...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Products, env
Share to Lipopolysaccharide Receptors
Share to Receptors, CXCR4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Serial Passage

Share to Simian Immunodeficiency Virus

Share to Viral Tropism

Share to Virus Attachment

Share to Virus Internalization

Source

Open in PubMed Open full text

Identifiers

PMID: 22830620
DOI: 10.1186/1742-4690-9-61
PMCID: PMC3418575

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22830620-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acquisition of CD4-dependence by CD4-independent SIV passaged in human peripheral blood mononuclear cells.PMID 22830620Read ↗

Decreased plasticity of coreceptor use by CD4-independent SIV Envs that emerge in vivo.Semantic proximity Read ↗

Characterization of a CD4-independent clinical HIV-1 that can efficiently infect human hepatocytes through chemokine (C-X-C motif) receptor 4Semantic proximity Read ↗

A species-specific amino acid difference in the macaque CD4 receptor restricts replication by global circulating HIV-1 variants representing viruses from recent infection.Semantic proximity Read ↗

Spontaneous mutations in the env gene of the human immunodeficiency virus type 1 NDK isolate are associated with a CD4-independent entry phenotype.Semantic proximity Read ↗

CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses.Semantic proximity Read ↗

Determinants of CD4 independence for a human immunodeficiency virus type 1 variant map outside regions required for coreceptor specificity.Semantic proximity Read ↗

HIV biological variability unveiled: frequent isolations and chimeric receptors reveal unprecedented variation of coreceptor use.Semantic proximity Read ↗

Isolation of CD4-independent primary human immunodeficiency virus type 1 isolates that are syncytium inducing and acutely cytopathic for CD8+ lymphocytes.Semantic proximity Read ↗

CD4-independent binding of SIV gp120 to rhesus CCR5.Semantic proximity Read ↗

Asymmetric HIV-1 co-receptor use and replication in CD4(+) T lymphocytes.Semantic proximity Read ↗

Identification of Owl Monkey CD4 Receptors Broadly Compatible with Early-Stage HIV-1 Isolates.Semantic proximity Read ↗

Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency virusesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.