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Extensive stage-regulation of translation revealed by ribosome profiling of Trypanosoma brucei

20 Oct 2014

Abstract excerpt

BACKGROUND: Trypanosoma brucei subspecies infect humans and animals in sub-Saharan Africa. This early diverging eukaryote shows many novel features in basic biological processes, including the use of polycistronic transcription to generate all protein-coding mRNAs. Therefore we hypothesized that translational control provides a means to tune gene expression during parasite development in mammalian and fly hosts....

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PMID: 25331479
DOI: 10.1186/1471-2164-15-911

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