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Article

Gene Delivery Using Herpes Simplex Virus Vectors

1 Dec 2002

Abstract excerpt

Herpes simplex virus (HSV) is a neurotropic DNA virus with many favorable properties as a gene delivery vector. HSV is highly infectious, so HSV vectors are efficient vehicles for the delivery of exogenous genetic material to cells. Viral replication is readily disrupted by null mutations in immediate early genes that in vitro can be complemented in trans, enabling straightforward production of high-titre pure...

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PMID: 12573050
DOI: 10.1089/104454902762053864

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