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Article

Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells.

The Journal of biological chemistry - 7 Nov 2008

Lin Wenwei, Wu Jing, Dong Hanqing, Bouck David, Zeng Fu-Yue, Chen Taosheng

Abstract excerpt

The human pregnane X receptor (hPXR) regulates the expression of critical drug metabolism enzymes. One of such enzymes, cytochrome P450 3A4 (CYP3A4), plays critical roles in drug metabolism in hepatocytes that are either quiescent or passing through the cell cycle. It has been well established that the expression of P450, such as CYP3A4, is markedly reduced during liver development or regeneration. Numerous...

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Identifiers

PMID: 18784074
DOI: 10.1074/jbc.M806132200
PMCID: PMC2662154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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