Article
Short-coupled polymorphic ventricular tachycardia at rest linked to a novel ryanodine receptor (RyR2) mutation: leaky RyR2 channels under non-stress conditions.
International journal of cardiology - 1 Feb 2015
Cheung Jim W, Meli Albano C, Xie Wenjun, Mittal Suneet, Reiken Steven, Wronska Anetta, Xu Linna, Steinberg Jonathan S, Markowitz Steven M, Iwai Sei, Lacampagne Alain, Lerman Bruce B, Marks Andrew R
Abstract excerpt
BACKGROUND: Ryanodine receptor (RyR2) mutations have largely been associated with catecholaminergic polymorphic ventricular tachycardia (PMVT). The role of RyR2 mutations in the pathogenesis of arrhythmias and syncope at rest is unknown. We sought to characterize the clinical and functional characteristics associated with a novel RyR2 mutation found in a mother and daughter with PMVT at rest. METHODS AND RESULTS:...
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