Article
Connection domain mutations during antiretroviral treatment failure in Mali: frequencies and impact on reverse transcriptase inhibitor activity.
Journal of acquired immune deficiency syndromes (1999) - 1 Nov 2012
Maiga Almoustapha Issiaka, Penugonda Sudhir, Katile Drissa, Diallo Fodie, Fofana Djeneba Bocar, Berzins Baiba, Maiga Moussa Youssouffa, Sylla Aliou, Traore Hamar Alassane, Marcelin Anne-Genevieve, Calvez Vincent, Tounkara Anatole, Bellosillo Nobel, Murphy Robert, Taiwo Babafemi
Abstract excerpt
Mutations in the connection domain (CD) of reverse transcriptase have been implicated in reverse transcriptase inhibitor (RTI) resistance, but this is controversial and little is known in non-B subtype HIV-1. We determined CD mutations prevalence in a population infected predominantly with CRF02_AG and investigated associations with phenotypic RTI resistance. Detected CD mutations were G335D (82.3%), A371V...
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