Article
Evolution of genetic diversity and drug resistance mutations in HIV-1 among untreated patients from Mali between 2005 and 2006.
The Journal of antimicrobial chemotherapy - 1 Sept 2008
Derache Anne, Maiga Almoustapha-Issiaka, Traore Ousmane, Akonde Alain, Cisse Mamadou, Jarrousse Bernard, Koita Victoria, Diarra Bah, Carcelain Guislaine, Barin Francis, Pizzocolo Cecilia, Pizarro Louis, Katlama Christine, Calvez Vincent, Marcelin Anne-Geneviève
Abstract excerpt
OBJECTIVES: To describe HIV-1 variants circulating in Mali and to estimate the rate of transmission of HIV-1 drug resistance in 2006. PATIENTS AND METHODS: Viral reverse transcriptase (RT) and protease (PR) genes from 198 antiretroviral (ARV)-naive patients diagnosed HIV-1 positive in May 2006 in Bamako and Segou were sequenced. RESULTS: Although CRF02_AG was always the predominant HIV-1 subtype observed (72%), a...
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