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Article

Connection domain mutations in treatment-experienced patients in the OPTIMA trial.

Journal of acquired immune deficiency syndromes (1999) - 1 Jun 2010

Dau Birgitt, Ayers Dieter, Singer Joel, Harrigan P Richard, Brown Sheldon, Kyriakides Tassos, Cameron D William, Angus Brian, Holodniy Mark

Abstract excerpt

OBJECTIVES: To determine the frequency of mutations in the connection domain (CD) of HIV reverse transcriptase in treatment-experienced patients in the Options in Management with Antiretrovirals trial, their impact on susceptibility to antiretroviral (ARV) drugs, and their impact on virologic outcomes. METHODS: Baseline plasma ARV genotypes and inferred resistance phenotypes were obtained. Frequencies of E312Q,...

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Identifiers

PMID: 20130473
DOI: 10.1097/QAI.0b013e3181cbd235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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