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Article

Adaptive evolution of Toll-like receptor 5 in domesticated mammals.

BMC evolutionary biology - 24 Jul 2012

Smith Sarah A, Jann Oliver C, Haig David, Russell George C, Werling Dirk, Glass Elizabeth J, Emes Richard D

Abstract excerpt

BACKGROUND: Previous studies have proposed that mammalian toll like receptors (TLRs) have evolved under diversifying selection due to their role in pathogen detection. To determine if this is the case, we examined the extent of adaptive evolution in the TLR5 gene in both individual species and defined clades of the mammalia. RESULTS: In support of previous studies, we find evidence of adaptive evolution of...

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Identifiers

PMID: 22827462
DOI: 10.1186/1471-2148-12-122
PMCID: PMC3483281

Genes

TLR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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