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Article

Hax-1 is rapidly degraded by the proteasome dependent on its PEST sequence.

BMC cell biology - 24 Jul 2012

Li Bin, Hu Qingsong, Xu Ranjie, Ren Haigang, Fei Erkang, Chen Dong, Wang Guanghui

Abstract excerpt

BACKGROUND: HS-1-associated protein X-1 (Hax-1), is a multifunctional protein that has sequence homology to Bcl-2 family members. HAX-1 knockout animals reveal that it plays an essential protective role in the central nervous system against various stresses. Homozygous mutations in the HAX-1 gene are associated with autosomal recessive forms of severe congenital neutropenia along with neurological symptoms. The...

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Identifiers

PMID: 22827267
DOI: 10.1186/1471-2121-13-20
PMCID: PMC3432607

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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