Article
TLR-4-dependent and -independent mechanisms of fetal brain injury in the setting of preterm birth.
Reproductive sciences (Thousand Oaks, Calif.) - 1 Aug 2012
Breen Kelsey, Brown Amy, Burd Irina, Chai Jinghua, Friedman Alexander, Elovitz Michal A
Abstract excerpt
In this study, we sought to assess how essential activation of toll-like receptor 4 (TLR-4) is to fetal brain injury from intrauterine inflammation. Both wild-type and TLR-4 mutant fetal central nervous system cells were exposed to inflammation using lipopolysaccharide in vivo or in vitro. Inflammation could not induce neuronal injury in the absence of glial cells, in either wild-type or TLR-4 mutant neurons....
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