Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation.

doi:10.1056/NEJMoa1211161

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Article

Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation.

The New England journal of medicine - 30 Jan 2014

Cunha Cristina, Aversa Franco, Lacerda João F, Busca Alessandro, Kurzai Oliver, Grube Matthias, Löffler Jürgen, Maertens Johan A, Bell Alain S, Inforzato Antonio, Barbati Elisa, Almeida Bruno, Santos e Sousa Pedro, Barbui Anna, Potenza Leonardo, Caira Morena, Rodrigues Fernando, Salvatori Giovanni, Pagano Livio, Luppi Mario, Mantovani Alberto, Velardi Andrea, Romani Luigina, Carvalho Agostinho

Abstract excerpt

BACKGROUND: The soluble pattern-recognition receptor known as long pentraxin 3 (PTX3) has a nonredundant role in antifungal immunity. The contribution of single-nucleotide polymorphisms (SNPs) in PTX3 to the development of invasive aspergillosis is unknown. METHODS: We screened an initial cohort of 268 patients undergoing hematopoietic stem-cell transplantation (HSCT) and their donors for PTX3 SNPs modifying the...

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PMID: 24476432
DOI: 10.1056/NEJMoa1211161

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PTX3

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