Article
Elevated plasma level of Pentraxin 3 is associated with emphysema and mortality in smokers.
Thorax - 1 Apr 2021
Zhang Yingze, Tedrow John, Nouraie Mehdi, Li Xiaoyun, Chandra Divay, Bon Jessica, Kass Daniel J, Fuhrman Carl R, Leader Joseph K, Duncan Steven R, Kaminski Naftali, Sciurba Frank C
Abstract excerpt
BACKGROUND: Pentraxin 3 (PTX3) influences innate immunity and inflammation, host defence, the complement cascade and angiogenesis. PTX3 expression in lung and blood of subjects with tobacco exposure, and its potential relationship with disease pattern and clinical outcome are poorly understood. METHODS: Using independent platforms and cohorts, we identified associations of PTX3 gene expression in lung tissue and...
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