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Article

The congenital bicuspid aortic valve can experience high-frequency unsteady shear stresses on its leaflet surface.

American journal of physiology. Heart and circulatory physiology - 15 Sept 2012

Yap Choon Hwai, Saikrishnan Neelakantan, Tamilselvan Gowthami, Vasilyev Nikolai, Yoganathan Ajit P

Abstract excerpt

The bicuspid aortic valve (BAV) is a common congenital malformation of the aortic valve (AV) affecting 1% to 2% of the population. The BAV is predisposed to early degenerative calcification of valve leaflets, and BAV patients constitute 50% of AV stenosis patients. Although evidence shows that genetic defects can play a role in calcification of the BAV leaflets, we hypothesize that drastic changes in the...

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Source

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Identifiers

PMID: 22821994
DOI: 10.1152/ajpheart.00829.2011
PMCID: PMC3468455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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