Article
An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks.
The EMBO journal - 12 Sept 2012
Hegnauer Anna Maria, Hustedt Nicole, Shimada Kenji, Pike Brietta L, Vogel Markus, Amsler Philipp, Rubin Seth M, van Leeuwen Fred, Guénolé Aude, van Attikum Haico, Thomä Nicolas H, Gasser Susan M
Abstract excerpt
DNA replication fork stalling poses a major threat to genome stability. This is counteracted in part by the intra-S phase checkpoint, which stabilizes arrested replication machinery, prevents cell-cycle progression and promotes DNA repair. The checkpoint kinase Mec1/ATR and RecQ helicase Sgs1/BLM...
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