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Article

Abnormal vasculature interferes with optic fissure closure in lmo2 mutant zebrafish embryos.

Developmental biology - 15 Sept 2012

Weiss Omri, Kaufman Rivka, Michaeli Natali, Inbal Adi

Abstract excerpt

Ocular coloboma is a potentially blinding congenital eye malformation caused by failure of optic fissure closure during early embryogenesis. The optic fissure is a ventral groove that forms during optic cup morphogenesis, and through which hyaloid artery and vein enter and leave the developing eye, respectively. After hyaloid artery and vein formation, the optic fissure closes around them. The mechanisms...

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Identifiers

PMID: 22819672
DOI: 10.1016/j.ydbio.2012.06.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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