Article
HLA class I protective alleles in an HIV-1-infected subject homozygous for CCR5-Δ32/Δ32.
Immunobiology - 1 Apr 2013
Ballana Ester, Riveira-Munoz Eva, Pou Christian, Bach Vanessa, Parera Mariona, Noguera Marc, Santos José R, Badia Roger, Casadellà Maria, Clotet Bonaventura, Paredes Roger, Martínez Miguel Angel, Brander Christian, Esté José A
Abstract excerpt
Homozygosity for a 32 bp deletion in CCR5 (CCR5-Δ32/Δ32) is associated with strong resistance against HIV-1 infection. Several HLA types have been associated to improved viral control and/or delayed progression to AIDS. We report a unique HIV-1 infected individual homozygous for CCR5-Δ32/Δ32 and carrier of HLA-A*2402 and HLA-B*5701. In comparison with earlier data and although a replication competent virus has...
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