Article
Association between genetic variants in pre-microRNAs and survival of early-stage NSCLC.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jun 2013
Hong Mi Jeong, Choi Yi Young, Jang Ji-Ae, Jung Hye-Jin, Lee Shin Yup, Lee Won Kee, Yoo Seung Soo, Lee Jaehee, Cha Seung Ick, Kim Chang Ho, Lee Eungbae, Jeon Hyo-Sung, Son Ji Woong, Park Jae Yong
Abstract excerpt
INTRODUCTION: MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators. Recent evidence indicates that altered miRNA expression plays an important role in the initiation and progression of lung cancer. Single nucleotide polymorphisms (SNPs) in pre-miRNAs could alter miRNAs processing, or expression, and hence, could influence the prognosis of lung cancer....
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