Article
Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers.
Clinical chemistry and laboratory medicine - 9 Sept 2011
Vinci Serena, Gelmini Stefania, Pratesi Nicola, Conti Simona, Malentacchi Francesca, Simi Lisa, Pazzagli Mario, Orlando Claudio
Abstract excerpt
BACKGROUND: The presence of sequence variants in miRNA genes may influence their processing, expression and binding to target mRNAs. Since single miRNA can have a large number of potential mRNA targets, even minor variations in its expression can have influences on hundreds of putative mRNAs. METHODS: Here, we evaluated 101 paired samples (cancer and normal tissues) from non-small cell lung carcinoma (NSCLC)...
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