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Article

The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division.

Development (Cambridge, England) - 1 Jun 2007

Bonaccorsi Silvia, Mottier Violaine, Giansanti Maria Grazia, Bolkan Bonnie J, Williams Byron, Goldberg Michael L, Gatti Maurizio

Abstract excerpt

We have isolated lethal mutations in the Drosophila lkb1 gene (dlkb1), the homolog of C. elegans par-4 and human LKB1 (STK11), which is mutated in Peutz-Jeghers syndrome. We show that these mutations disrupt spindle formation, resulting in frequent polyploid cells in larval brains. In addition, dlkb1 mutations affect asymmetric division of larval neuroblasts (NBs); they suppress unequal cytokinesis, abrogate...

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Identifiers

PMID: 17507418
DOI: 10.1242/dev.02848

Genes

STK11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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