Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional co-activator p300 maintains basal hepatic gluconeogenesis.

The Journal of biological chemistry - 14 Sept 2012

He Ling, Naik Karuna, Meng Shumei, Cao Jia, Sidhaye Aniket R, Ma Anlin, Radovick Sally, Wondisford Fredric E

Abstract excerpt

A major cause of fasting hyperglycemia in diabetes mellitus is unregulated hepatic glucose production (HGP). Insulin suppresses HGP by phosphorylating CBP and disassembling the CREB-CBP complex from gluconeogenic genes. p300 is closely related to CBP; but in contrast to CBP, p300 binds constituti...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP Response Element-Binding Protein
Share to Gluconeogenesis
Share to Glucose

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucose Clamp Technique

Share to Hepatocytes

Share to Insulin

Share to p300-CBP Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 22815486
DOI: 10.1074/jbc.M112.385864
PMCID: PMC3442537

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22815486-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional co-activator p300 maintains basal hepatic gluconeogenesis.PMID 22815486Read ↗

Adaptive and maladaptive roles for ChREBP in the liver and pancreatic islets.Semantic proximity Read ↗

Regulation of Hepatic Metabolism and Cell Growth by the ATF/CREB Family of Transcription FactorsSemantic proximity Read ↗

Emerging roles of p300/CBP in autophagy and autophagy-related human disordersSemantic proximity Read ↗

Is histone acetylation the most important physiological function for CBP and p300?Semantic proximity Read ↗

Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis.Semantic proximity Read ↗

Cannabinoid receptor type 1 (CB1R) signaling regulates hepatic gluconeogenesis via induction of endoplasmic reticulum-bound transcription factor cAMP-responsive element-binding protein H (CREBH) in primary hepatocytes.Semantic proximity Read ↗

Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal.Semantic proximity Read ↗

The role of CREB-H transcription factor in triglyceride metabolism.Semantic proximity Read ↗

Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous miceSemantic proximity Read ↗

Regulation of Hepatic Gluconeogenesis by an ER-Bound Transcription Factor, CREBHSemantic proximity Read ↗

Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells.Semantic proximity Read ↗

The Role of Mammalian Creb3-Like Transcription Factors in Response to NutrientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.