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Membrane-shaping host reticulon proteins play crucial roles in viral RNA replication compartment formation and function

30 Aug 2010

Abstract excerpt

Positive-strand RNA viruses replicate their genomes on membranes with virus-induced rearrangements such as single- or double-membrane vesicles, but the mechanisms of such rearrangements, including the role of host proteins, are poorly understood. Brome mosaic virus (BMV) RNA synthesis occurs in ≈70 nm, negatively curved endoplasmic reticulum (ER) membrane invaginations induced by multifunctional BMV protein 1a....

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PMID: 20805477
DOI: 10.1073/pnas.1011105107

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