Article
Adenovirus type 5 exerts genome-wide control over cellular programs governing proliferation, quiescence, and survival
12 Apr 2007
Abstract excerpt
BACKGROUND: Human adenoviruses, such as serotype 5 (Ad5), encode several proteins that can perturb cellular mechanisms that regulate cell cycle progression and apoptosis, as well as those that mediate mRNA production and translation. However, a global view of the effects of Ad5 infection on such programs in normal human cells is not available, despite widespread efforts to develop adenoviruses for therapeutic...
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