Article
Genetic organization and diversity of the hepatitis C virus.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1991
Choo Q L, Richman K H, Han J H, Berger K, Lee C, Dong C, Gallegos C, Coit D, Medina-Selby R, Barr P J
Abstract excerpt
The nucleotide sequence of the RNA genome of the human hepatitis C virus (HCV) has been determined from overlapping cDNA clones. The sequence (9379 nucleotides) has a single large open reading frame that could encode a viral polyprotein precursor of 3011 amino acids. While there as little overall amino acid and nucleotide sequence homology with other viruses, the 5' HCV nucleotide sequence upstream of this large...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Genes, Viral
- Genetic Variation
- Hepacivirus
- Molecular Sequence Data
- Oligonucleotide Probes
- Pan troglodytes
- Protein Conformation