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Article

Phosphorylation of Ser711 residue in the hypervariable region of zoonotic genotype 3 hepatitis E virus is important for virus replication.

mBio - 13 Nov 2024

Wang Bo, Subramaniam Sakthivel, Tian Debin, Mahsoub Hassan M, Heffron C Lynn, Meng Xiang-Jin

Abstract excerpt

Hepatitis E virus (HEV) is distinct from other hepatotropic viruses because it is zoonotic. HEV-1 and HEV-2 exclusively infect humans, whereas HEV-3 and HEV-4 are zoonotic. However, the viral and/or host factors responsible for cross-species HEV transmission remain elusive. The hypervariable region (HVR) in HEV is extremely heterogenetic and is implicated in HEV adaptation. Here, we investigated the potential...

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Identifiers

PMID: 39377575
DOI: 10.1128/mbio.02635-24
PMCID: PMC11559016

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